WebCisplatin Relocalizes RNA Binding Protein HuR and Enhances the Oncolytic Activity of E4orf6 Deleted Adenovirus by Umma Habiba 1,2,*, Elora Hossain 3, Aya Yanagawa-Matsuda 4, Abu Faem Mohammad Almas Chowdhury 5, Masumi Tsuda 1,6,7, Asad-uz- Zaman 2, Shinya Tanaka 1,6,7 and Fumihiro Higashino 3,4,* 1 WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of …
Targeted therapy for cisplatin‐resistant lung cancer via …
WebCisplatin, cis - [PtCl 2 (NH 3) 2 ], is extensively used for the treatment of testicular and ovarian cancers and increasingly against other types of solid tumors (head/neck, lung, cervical, and bladder) ( 1 , 2 , 3 , 4 ). The cytotoxic effect of cisplatin is thought to be due to attack on DNA bases and induction of apoptosis in cancer cells ( 5 , 6 WebTargeted therapy for cisplatin‐resistant lung cancer via aptamer‐guided nano‐zinc carriers containing USP14 siRNA ... /PI3K/protein kinase B (AKT) signaling pathway, resulting in decreased DDP resistance in A549/DDP cells. ... Screening and characteristics of AM binding to A549/DDP using Cell‐SELEX. Accurate targeting is the key to ... how does a derecho form
SSBP1 single stranded DNA binding protein 1 [ (human)]
WebTherefore, the study is designed to investigate the regulatory function and mechanism of Taurine up-regulated gene 1 (TUG1) in the cisplatin resistance of CRC. qRT-PCR checked the expressions of TUG1, Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2), and miR-195-5p in CRC tissues and cells. WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. WebMay 15, 2016 · We summarize the structural features of known cisplatin-protein adducts. • Key characteristics of the cisplatin modes of binding to proteins are described. • … phool aur patthar 1966