Ctld1
WebAbstract. Anti-phospholipase A2 receptor autoantibody (PLA2R-Ab) plays a critical role in the pathogenesis of primary membranous nephropathy (PMN), an autoimmune kidney … WebSep 1, 2024 · M-type phospholipase A2 receptor (PLA2R) is a member of the mannose receptor family. Recent evidence shows that PLA2R is a major autoantigen causing …
Ctld1
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WebDec 8, 2024 · CTLD1 is a part of the smaller ring and stays on the top of the molecule, while CTLD7 hides beneath the double-ring-shaped head of M-PLA2R (Fig. 2). Although the binding assays of autoantibodies to M-PLA2R indicate that their interactions are pH-independent [26] ... WebRecombinant Human PLA2R1-CTLD1 Protein. Question / Bulk Inquiry. Please leave us a message if you have any questions or have bulk order inquiry, we will get back to you in …
WebNov 14, 2014 · Results: Our results showed that the anti-PLA2R antibodies from patients specifically recognize a three domain structure consisting of the CysR, FnII, and the CTLD1 domains under non-reducing ... Web(A) The cartoon shows the constructs with the 1–3 construct or CTLD1 domain deletion and a full-length PLA 2 R with an introduced thrombin digestion site between CTLD1 and CTLD2 domains. Deleted ...
WebDownload scientific diagram Validation of three epitope-specific ELISAs using CysR, CTLD1 and CTLD7 domains and reactivity of PLA2R1-positive patients with iMN. (A) ELISAs were validated with ... WebDNA profiling studies [1,2] have shown that DLD-1 ( ATCC CCL-221 ), HCT-15 ( ATCC CCL-225 ), HCT-8 ( ATCC CCL-244) and HRT-18G (ATCC CRL-11663) share a single …
WebJun 13, 2003 · The right panel shows the structure of the wild-type Endo180 protein and the Endo180 protein from ΔEx2–6/ΔEx2–6 cells, which is …
WebBackground. Secretory phospholipases A2 (PLA2s) have been purified from a variety of mammalian tissues as well as from insect and snake venoms. The prototype group I PLA2, the pancreatic PLA2 (PLA2G1B; MIM 172410), is involved in digestion, smooth muscle contraction, and cell proliferation. The prototype group II PLA2, the inflammatory-type ... software uvigoWebMar 30, 2024 · The patients with antibodies targetting CysR only are considered as non-spreaders, while the patients additionnaly targetting either CTLD1 and/or CTLD7 are … slow release balanced 10-10-10 fertilizerWebAug 13, 2024 · Background: Membranous Nephropathy (MN) is a rare autoimmune disease related to PLA2R1 antibodies in 70% of cases. One third of patients enter in spontaneous remission. PLA2R1 epitopes in MN have been characterized in four different domains of PLA2R1 and a mechanism of epitope spreading from the immunodominant CysR domain … software utwenteWebApr 22, 2024 · The four N-terminal domains (Cys-R, FNII, CTLD1 and CTLD2) form an area known as the ligand-binding region (LBR), which makes the protein able to bind collagens and carbohydrates (Fig. 1). The Cys-R domain of uPARAP/Endo180 has a unique conformation that differentiates it from the typical β-trefoil fold characteristic of other MR … software uwWebIt was also reported that four single-domain epitopes (CysR, CTLD1, CTLD7, and CTLD8) exist in the large PLA2R extracellular region (11,14,15), and that epitope spreading … slow release beta foodWebCells from the human MG-63 (Bone Osteosarcoma, ATCC CRL-1427) cell line were stained with PE Mouse IgG1, κ Isotype Control (Cat. No. 562438; dashed line histogram) or PE … slow release anxiety medicationWeb邢晖林,张娇,许清玉,郭明好 (新乡医学院第一附属医院 肾脏病医院,河南 新乡 453100) 原发性膜性肾病(primary membranous nephropathy,PMN)是一种自身免疫性肾小球疾病,其主要病理特征为IgG与抗原结合形成免疫复合物,聚集于肾小球毛细血管壁上皮下(外侧),免疫复合物进一步激活补体系统,形成膜 ... software uwe