site stats

Cyclothialidine

WebAug 15, 2007 · From the SAR around cyclothialidine 2 we know that the introduction of a methoxy and a carboxylic ester group in the meta positions and a lipophilic group (like methyl) in para position to the phenol improves activity. Therefore we coupled the salicylic aldehyde 4a with various anilines to yield the acyclic benzylic amines 5 and the 2,3 … WebNov 11, 2003 · Concise Synthesis of Cyclothialidine Analogues (VI) with Ring Sizes from 12 to 15: Novel Macrocyclization Protocol Involving Reductive Thiolation. J. Geiwiz, J. Geiwiz. Pharma Div., Chem. Technol., F. Hoffmann-La Roche AG, CH-4070 Basel, Switz. Search for more papers by this author.

In silico discovery of 2-amino-4-(2,4-dihydroxyphenyl)thiazoles as ...

WebJan 15, 2024 · Cyclothialidine Chemsrc provides cyclothialidine (CAS#:147214-63-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of cyclothialidine are included as well. >> amp version: cyclothialidine WebAug 26, 2024 · Cyclothialidine inhibits the ATPase activity of gyrase by competing for the ATP binding site . The precise mode of action of these agents with gyrase is incompletely understood, although ... dynamic pool error hypixel https://obandanceacademy.com

Total Synthesis of Cyclothialidine Semantic Scholar

WebJan 1, 1993 · Cyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any growth-inhibitory activity … WebTheir structures have been elucidated based on the amino acid analysis of the hydrolysates, NMR and HRFAB-MS experiments and shown to be cyclothialidine analogs. The … WebCyclothialidine Alternative Names: RO 091437 Latest Information Update: 18 Jul 2000. Price : $50 * Buy Profile. Adis is an information provider. We do not sell or distribute actual drugs. Final gross price and currency may vary according to local VAT and billing address. Your purchase entitles you to full access to the information contained in ... crystal vision pdf

Thieme E-Journals - Synthesis / Abstract

Category:Fabienne RICKLIN Roche, Basel Department of Discovery …

Tags:Cyclothialidine

Cyclothialidine

From Bacteria to Cancer: A Benzothiazole-Based DNA

WebCyclothialidine is a new, potent DNA gyrase inhibitor isolated from Streptomyces filipinensis. However, it exhibits hardly any growth-inhibitory activity against intact … WebCyclothialidine: ChEBI ID CHEBI:29566: Stars This entity has been manually annotated by a third party. Supplier Information Download Molfile XML SDF: Find compounds which contain this structure; Find compounds which resemble this structure; Take structure to the Advanced Search ...

Cyclothialidine

Did you know?

WebJun 16, 1995 · Cyclothialidine contains a unique 12-membered lactone ring that is partly integrated into a pentapeptide chain(21). Cyclothialidine exhibited the highest …

WebFeb 1, 2010 · The crystal structures of compounds 1 and 2 23 with 24 kDa N-terminal fragment of the DNA gyrase B protein offer valuable information for lead optimization process. It has been demonstrated that the noviose sugar of novobiocin (1) and resorcinol moiety of cyclothialidine GR122222X (2) are involved in a similar H-bond network … WebApr 1, 1996 · We present the structures of a 24 kDa N-terminal fragment of the Escherichia coli DNA gyrase B protein in complexes with two different inhibitors of the ATPase activity of DNA gyrase, namely the...

WebCyclothialidine C C26H35N5O11S CID 10699166 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, … WebAbstract. The DNA gyrase inhibitor cyclothialidine was shown to be an interesting lead structure for the search of new antibacterials. During extensive work elucidating the structure-activity relations, it was demonstrated that variation of the lactone ring size of its bicyclic core was tolerated. Indeed, even ‘ seco ’ analogues exhibited ...

WebCyclothialidine is an inhibitor of DNA gyrase. All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use. Cyclothialidine, CAS 147214-63-9 Please contact us for prices and availability for the specification of product you are interested at. Product consultation Purity : 98%

WebA total synthesis of cyclothialidine (1), a new DNA gyrase inhibitor isolated from Streptomyces filipinensis, is described. The synthetic concept was tested by preparing the lactone 13(Scheme 2) which contains the characteristic bicyclic core entity of 1. crystal vision pill reviewsWebJan 1, 1993 · CYCLOTHIALIDINE, A NOVEL DNA GYRASE INHIBITOR 3.1. DISCOVERY, ISOLATION AND STRUCTURE ELUCIDATION The therapeutic progress achieved with … dynamic pools chinderahWebDescription: Cyclothialidine is a DNA gyrase inhibitor; isolated from Streptomyces filipinensis. Chemical Structure Cyclothialidine CAS# 147214-63-9 Instruction Theoretical Analysis MedKoo Cat#: 596819 … crystal vision phone numberWebDec 11, 1996 · A total synthesis of cyclothialidine (1), a new DNA gyrase inhibitor isolated from Streptomyces filipinensis, is described. The synthetic concept was … crystal vision packaging coWebOct 1, 1994 · We investigated how cyclothialidine (Ro 09-1437), a novel DNA gyrase inhibitor belonging to a new chemical class of compounds, acts to inhibit Escherichia coli DNA gyrase. Cyclothialidine up to... crystal vision philipsWebCyclothialidine (Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from S. filipinensis NR0484. In this account we describe the identification of potent antibacterials structurally... crystal vision musicWebMar 15, 1996 · We present the structures of a 24 kDa N-terminal fragment of the Escherichia coli DNA gyrase B protein in complexes with two different inhibitors of the ATPase activity of DNA gyrase, namely the coumarin antibiotic, novobiocin, and GR122222X, a member of the cyclothialidine family. dynamic polymorphism vs runtime polymorphism