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High dose statins in elderly

WebHigh doses or high-potency statins in elderly people may not increase effectiveness, but may increase the risk of adverse effects such as muscle-related aches, pains and weakness. Hence, statin use in the elderly requires frequent review and consideration of their therapeutic goals, quality of life, risk–benefit ratio and life expectancy. WebRhabdomyolysis can cause severe muscle pain, liver damage, kidney failure and death. The risk of very serious side effects is extremely low, and calculated in a few cases per …

Statins and the elderly: recent evidence and current indications

WebFor primary prevention of CVD, high-intensity statin treatment (atorvastatin 20 mg daily) should be considered in people (without the need for a formal risk assessment): With … Web12 de mar. de 2024 · Khush KK, Waters DD, Bittner V, et al. Effect of high-dose atorvastatin on hospitalizations for heart failure: subgroup analysis of the Treating to New Targets (TNT) study. Circulation 2007; 115:576. Horwich TB, MacLellan WR, Fonarow GC. Statin therapy is associated with improved survival in ischemic and non-ischemic heart … citrix atlantic health https://obandanceacademy.com

Primary Prevention With Statins in the Elderly - American …

Web29 de out. de 2024 · That's due to a lack of studies assessing the safety and effectiveness of statins for people in this age group. "There are no clear guidelines after 75,” says cardiologist Dara Lee Lewis, M.D., an associate physician and instructor in medicine at Brigham and Women's Hospital in Boston. “And it has been difficult as a provider, … WebNational Center for Biotechnology Information Web12 de abr. de 2024 · Moderate-intensity statin with ezetimibe combination therapy was associated with lower rates of intolerance-related drug discontinuation or dose reduction among patients aged ≥75 years (2.3% vs. 7.2%; p = 0.010) and those aged <75 years (5.2% vs. 8.4%; p < 0.001) (p for interaction = 0.159). Median LDL-C levels were 58 mg/dL in … dickinson isd careers

Secondary Prevention of Atherosclerotic Cardiovascular Disease …

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High dose statins in elderly

National Center for Biotechnology Information

WebManaging hypercholesterolemia and preventing cardiovascular events in elderly and younger Chinese adults: focus on rosuvastatin Zhen Wang, Junbo GeDepartment of Cardiology, Zhongshan Hospital, Shanghai, People's Republic of ChinaAbstract: Coronary heart disease (CHD) is the leading cause of death worldwide. The efficacy and safety of … Web26 de fev. de 2024 · The American College of Cardiology/American Heart Association (ACC/AHA) task force on clinical practice guidelines has updated its 2013 cholesterol …

High dose statins in elderly

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Web18 de mar. de 2024 · Statins are drugs that can lower your cholesterol. They work by blocking a substance your body needs to make cholesterol. Lowering cholesterol isn't the … Web2 de out. de 2024 · Statin drugs have been shown to reduce the risk of cardiovascular disease (CVD) in young and middle-aged adults. With older adults (those 75 and over), …

Web3 de abr. de 2024 · Importantly, however, the combination of moderate-intensity statins and ezetimibe was associated with lower rates of intolerance-related drug discontinuation or … Web17 de mar. de 2024 · The dose response and tolerance should be assessed in about 6-8 weeks. If LDL-C reduction is adequate (≥30% reduction with intermediate- and 50% with high-intensity statins), regular interval monitoring of risk factors and compliance with statin therapy are necessary to determine adherence and adequacy of effect (about 1 year).

Web19 de jul. de 2024 · A specific high-dose preparation (4 grams per day of icosapent ethyl or 1800 mg per day of highly purified EPA) has been found to reduce the risk of heart attack, stroke, need for stent of bypass surgery, and cardiac death when used with a statin in people who have mild hypertriglyceridemia (149 to 500 mg/dL) and either established … Web10 de mar. de 2015 · This forms the basis of the ACC/AHA recommendations on statins for primary prevention—namely, that statins are indicated for patients between 40 and 75 years of age with diabetes, LDL greater than 190, or a 10-year ASCVD risk of greater than 7.5%. While it has been estimated that 97% of individuals between 65 and 75 years of age …

WebManaging hypercholesterolemia and preventing cardiovascular events in elderly and younger Chinese adults: focus on rosuvastatin Zhen Wang, Junbo GeDepartment of …

Web8 de mai. de 2024 · Statins have proved beneficial for the prevention of cardiovascular disease in adults, 1, 2, 3 but patients >75 years have been underrepresented in … citrix at turner cloudWebStatin treatment reduces cardiovascular morbidity and mortality in middle-aged adults. However, few studies have included older individuals, particularly those aged 80 years or … citrix atlasair access gatewayWeb2 de jan. de 2024 · Recommended statins based on low-density lipoprotein cholesterol (LDL-C) before treatment is 70-189 mg/dl in the age range of 40-75 years in the ACC/AHA who require a ≥7.5% 10-year risk to be eligible. In contrast, in the NICE-UK, which apply to 30-84 years, high-intensity treatment is recommended regardless of LDL-C if 10-year … dickinson isd salary scheduleWebThe USPSTF concludes with moderate certainty that initiating use of low- to moderate-dose statins for the prevention of CVD events and mortality in adults aged 40 to 75 years without a history of ... dickinson isd school busWeb3 de mai. de 2024 · The recommended dose is: 30. Five-year CVD risk 5–15%: 10–20 mg atorvastatin (max 80 mg daily) Five-year CVD risk > 15% (including those with known CVD): 10–40 mg atorvastatin (max 80 mg daily) It is recommended to monitor non-fasting lipids every six-to-twelve months until the desired target is reached. citrix atrius healthWebRecent meta-analyses have shown that statins are associated with a small incremental increase in the risk of incident diabetes with a number needed to harm of about 255 for statin versus placebo and 125 for high-dose versus moderate-dose statin over 4 years, which are much higher than the number needed to treat to prevent one CV event. dickinson isd school calendar 2021WebA recent retrospective cohort study that researched the impact of statins on older people with diabetes mellitus showed a small statin benefit in those 75 to 85 years of age. 9 … citrix atlantichealth remote access