WebJun 19, 2024 · IRF8 is a critical transcription regulator for myeloid lineage commitment. 1 Loss of Irf8 leads to expansion of neutrophils with a significant reduction in macrophages and dendritic cells. 2,... WebOct 1, 2009 · It has been shown that IRF8 represses Bcl-2 expression in myeloid cells in vitro (39). However, it has also been shown that IRF8 does not regulate Bcl-2 expression in …
The IRF family of transcription factors: Inception, impact and ...
WebNov 1, 2012 · IRF8 is a key transcription factor for myeloid cell differentiation, and its expression is frequently lost in hematopoietic cells obtained from myeloid leukemia patients. Accumulating evidence indicates an antagonizing relationship between IRF8 and myeloid leukemia, in particular chronic myelogenous leukemia (CML). mcnick high school
用于治疗AML和MDS的RARA激动剂专利检索-抗肿瘤药专利检索查 …
Web1.一种包含rara(视黄酸受体α)激动剂的药物组合物,其用于治疗受试者中的癌症,其中: 所述受试者的癌细胞经判断具有irf8生物标志物、rara生物标志物,或irf8生物标志物和rara生物标志物,其中: 所述irf8生物标志物是或包括irf8基因相关的超级增强子或等于或高于预定阈值的irf8 rna转录物水平; 所述 ... WebRapid transcription factor degradation followed by measurements of genome-wide transcription rates and superresolution microscopy revealed that MEF2D and IRF8 form a distinct core regulatory module with a narrow direct transcriptional program that includes activation of the key oncogenes MYC, HOXA9, and BCL2. WebInterferon regulatory factor 8 (Irf8), also known as interferon consensus sequence-binding protein, is a component of the Irf transcription factor family. Irf8 is differentially expressed … mcnichols trench drain